Bioactive Small Molecules
Abcam STO-609 acetate, CaM-KK inhibitor, 25MG
MW 374.3 Da, Purity >98%. Potent, competitive, selective and cell-permeable inhibitor of CaM-KK (Ki values are0.21 μM and 40 nM for CaM-KKα and CaM-KKβ respectively). Potent, competitive AhR agonist (EC₅₀ = 43 nM). Active in vivo..
The product is subject to the following: Abcam Restricted Use Statement
eMolecules 2086301-47-3 | Medchem Express | (SRS)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH | 10mg | 633697026 | HY-131168 | 1509.98 | C78H116N12O14S2
ChemScene | 5-Bromo-13-dihydrobenzoimidazol-2-one | 1g | 491371333 | CS-W005438 | 39513-26-3 | MFCD28947289 | 213.034 | C7H5BrN2O
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Cayman Chemical ANTIBODY Metolazon 10mg
A thiazide-like diuretic; inhibits the Na+/Cl- cotransporter (IC50 = 0.3 µM for the rat transporter) and CAVII, CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively); induces fluid loss and enhances captopril-induced decreases in blood pressure in spontaneously hypertensive rats at 0.3 and 1 mg/kg
Medchemexpress LLC Echitamine chloride | 6878-36-0 | 1 MG
Echitamine chloride, also known as Ditaine chloride, is a prominent monoterpene indole alkaloid found in Alstonia scholaris. It is known for its potent anti-tumour properties, operating by inducing DNA fragmentation and promoting cell apoptosis. Additionally, it acts as an inhibitor of pancreatic lipase.
- Potent anti-tumor activity
- Induces DNA fragmentation
- Promotes cell apoptosis
- Inhibits pancreatic lipase with an IC50 of 10.92 μM
Medchemexpress LLC Diiodohydroxyquinoline | 83-73-8 | 98.0% | 1 ML
Diiodohydroxyquinoline (Iodoquinol) is a compound with orally active antiparasitic properties. It exhibits potent anti-SARS-CoV-2 activity with an EC50 value of 1.38 μM in VeroE6 cells, and its antimutagen is ascorbic acid. This compound shows promise for research in inflammation, intestinal amebiasis, amebic liver abscess, and chronic nonspecific diarrheas.
- Possesses orally active antiparasitic properties.
- Exhibits mutagenic potential in mice.
- Shows potent anti-SARS-CoV-2 activity with an EC50 of 1.38 μM in VeroE6 cells.
- Antimutagen is ascorbic acid.
- Useful for research in inflammation.
- Useful for research in intestinal amebiasis.
- Useful for research in amebic liver abscess.
- Useful for research in chronic nonspecific diarrheas.
Cayman Chemical ANTIBODY CYT997 5mg
An inhibitor of microtubule polymerization (IC50 = ~3 µM); induces cell cycle arrest at the G2/M phase; cytotoxic against a panel of cancer cell lines (IC50s = 0.009-0.101 µM); increases HUVEC monolayer permeability (IC50 = ~0.08 µM); decreases liver metastasis in a murine DMH-induced colon cancer model at 5, 10, and 15 mg/kg
Cayman Chemical ANTIBODY SR 0987 5mg
An agonist of RORγt, inducing reporter gene expression with an EC50 value of ~800 nM; increases expression of IL-17, while decreasing expression of PD-1, in a variety of T cells
Medchemexpress LLC Thalidomide-Piperazine-PEG1-NH2 (diTFA) | 657.52 | 100 MG
Thalidomide-Piperazine-PEG1-NH2 (diTFA) is a chemical compound primarily intended for laboratory research and the manufacture of various substances. Presented as a solid, this product has a molecular weight of 657.52. It is designed for experienced personnel and research applications only, and has not been fully validated for medical uses. Proper storage is crucial: the recommended temperature is 4°C in sealed containers away from moisture. If stored in solvent, it can be kept at -80°C for 6 months or -20°C for 1 month, also in sealed conditions away from moisture.
- Designed for laboratory research applications
- Suitable for experienced personnel
- Molecular weight of 657.52
- Appears as a solid
- Store at 4°C, sealed, away from moisture
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC BMS-5 | 1338247-35-0 | 431.29 | 1 ML
BMS-5 (LIMKi 3) is a potent LIM kinase (LIMK) inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. This compound is used in cancer research and inhibits cofilin-Ser3 phosphorylation in a dose-dependent manner.
- Potent LIM kinase inhibitor
- IC50 of 7 nM for LIMK1
- IC50 of 8 nM for LIMK2
- Target: LIM Kinase
- Research area: Cancer
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 2 years, -20°C for 1 year
- Solubility in DMSO: 100 mg/mL
- Reduces Nf2∆Ex2 MSC viability
Abcam C75, fatty acid synthase (FAS) inhibitor, 1MG
MW 254.32 Da, Purity >98%. Competitive, irreversible fatty acid synthase (FAS) inhibitor (IC₅₀ = 200 μM). Suppresses expression of neuropeptide Y and agouti-related protein. Antitumor and anti-obesity agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical ANTIBODY BI-749327 1mg
A TRPC6 inhibitor (IC50 = 13 nM for the mouse channel); selective for TRPC6 over TRPC3 and TRPC7 (IC50s = 1,100 and 550 nM, respectively, for the mouse channels); inhibits TRPC6-mediated reporter gene expression in HEK293T cells expressing mouse TRPC6 at 100, 250, and 500 nM; decreases myocardial interstitial fibrosis in a mouse model of hypertrophic cardiomyopathy induced by transaortic constriction at 30 mg/kg; reduces unilateral ureteral obstruction-induced renal fibrosis in mice; increases survival, decreases myocardial fibrosis, and improves grip strength in a mouse model of DMD at 30 mg/kg
Medchemexpress LLC HY-14768 50mg , Favipiravir CAS:259793-96-9 Purity:>98%
HY-14768 50mg Favipiravir CAS: 259793-96-9 Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC50 of 341 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY ITH15004 5mg
A P2X7 receptor antagonist (IC50 = 9 µM); inhibits ATP-induced currents in X. laevis oocytes expressing the human P2X7 receptor at 100 µM; decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages at 1 µM; has high permeability in a PAMPA
Medchemexpress LLC 1-Naphthyl PP1 | 221243-82-9 | 99.4% | 317.39 | 1 ML
1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases and Protein Kinase D. It has a molecular formula of C19H19N5, a molecular weight of 317.39, and a purity of 99.36% by HPLC. It inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively.
- Selective inhibitor of src family kinases and Protein Kinase D.
- Inhibits v-Src, c-Fyn, c-Abl, CDK2, and CAMK II.
Abcam Necrosulfonamide, necroptosis inhibitor, 10MG
MW 461.5 Da, Purity >98%. Potent, selective necroptosis inhibitor (IC₅₀ = 0.2 μM). MLKL blocker. Selectively blocks necrosis downstream of RIP3 activation. Shows selective antinecrotic effects.
The product is subject to the following: Abcam Restricted Use Statement